PubMed 42659412

Vitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health

Menezes-Júnior L et al. · Sao Paulo medical journal = Revista paulista de medicina · 2026 · PubMed · DOI 10.1590/1516-3180.2025.2955.18032026

Summary

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Vitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health

随机对照试验Machine-checked 2026年9月21日AI-assisted draft

Menezes-Júnior L et al. Vitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health. Sao Paulo medical journal = Revista paulista de medicina, 2026. PubMed 42659412 · DOI

Design
Randomized, double-blind, placebo-controlled clinical trial.
Population
198 male shift workers at an iron ore extraction company in Minas Gerais, Brazil, with 25(OH)D concentrations under 30 ng/mL and at least one metabolic abnormality (metabolic syndrome, impaired fasting glucose, dyslipidemia, elevated blood pressure, or increased waist circumference).
Intervention
Cholecalciferol (vitamin D3) supplementation versus placebo.
Dose as studied
14,000 IU/week or 28,000 IU/week.
Comparator
Placebo.
Duration
4 months.

Outcomes, as reported

  • Waist circumference (WC) No significant difference between either vitamin D dose group and placebo after 4 months.
  • Waist-to-height ratio (WHtR) No significant difference between either vitamin D dose group and placebo after 4 months (p > 0.05).
  • Serum 25(OH)D concentration Increased +6.23 ng/mL (p25=0.58, p75=10.61) in the 14,000 IU/week group and +15.25 ng/mL (p25=10.57, p75=19.68) in the 28,000 IU/week group; placebo group decreased -0.50 ng/mL (p25=-1.03, p75=2.71).

Limitations stated by the authors · Not stated in the abstract.

Funding · Not stated in the abstract.