PubMed 42627860

Effects of folic acid combined with resistance training on body composition and blood biomarkers in adult males

Yang C et al. · Journal of the International Society of Sports Nutrition · 2026 · PubMed · DOI 10.1080/15502783.2026.2720733

Summary

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Effects of folic acid combined with resistance training on body composition and blood biomarkers in adult males

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Yang C et al. Effects of folic acid combined with resistance training on body composition and blood biomarkers in adult males. Journal of the International Society of Sports Nutrition, 2026. PubMed 42627860 · DOI

Design
Randomized controlled trial with four parallel groups (control, resistance training, folic acid, resistance training + folic acid). 8-week intervention preceded by a 1-week testing period. Within-group pre/post comparisons used paired t tests; between-group comparisons used one-way ANOVA.
Population
Forty healthy adult male college students, randomly divided into four groups of n = 10 each.
Intervention
Folic acid supplementation, given alone or combined with a resistance training program; other groups received resistance training alone or placebo.
Dose as studied
0.4 mg folic acid daily.
Comparator
Control group received one appearance-matched placebo tablet daily. Additional comparator groups received resistance training alone or folic acid alone.
Duration
8 weeks, preceded by a 1-week testing period.

Outcomes, as reported

  • Skeletal muscle mass (SMM) change RF +4.79 ± 2.42 kg vs control +0.96 ± 1.50 kg, FA +1.03 ± 1.68 kg, RT +0.91 ± 1.12 kg (all P < 0.01).
  • Body fat mass (BFM) change RF -1.49 ± 1.40 kg vs control +0.24 ± 1.71 kg (P < 0.01) and FA +0.04 ± 1.18 kg (P < 0.05).
  • Body fat percentage (BFP) change RF decreased significantly more than FA (P < 0.05).
  • Homocysteine (Hcy) RF decreased significantly relative to control and RT (both P < 0.05).
  • HDL-C change RF +0.21 ± 0.24 mmol/L vs control -0.01 ± 0.12 mmol/L (P < 0.01) and FA +0.02 ± 0.16 mmol/L (P < 0.05).
  • Folic acid concentration, TC, TG, LDL-C No significant between-group differences detected.

Limitations stated by the authors · Abstract does not detail limitations explicitly. Authors state findings should be interpreted as preliminary rather than definitive evidence of cardiometabolic benefit. Small group sizes (n = 10 per group) and an all-male sample are noted characteristics of the design.

Funding · Not stated in the abstract.