PubMed 42572961

Vitamin D status and supplementation in left ventricular remodeling in chronic kidney disease: A systematic review and meta-analysis

Fu S, Fu Q, Liao X · Biomolecules & biomedicine · 2026 · PubMed · DOI 10.17305/bb.2026.14486

Summary

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Vitamin D status and supplementation in left ventricular remodeling in chronic kidney disease: A systematic review and meta-analysis

Meta-analysisMachine-checked Sep 21, 2026AI-assisted draft

Fu S, Fu Q, Liao X Vitamin D status and supplementation in left ventricular remodeling in chronic kidney disease: A systematic review and meta-analysis. Biomolecules & biomedicine, 2026. PubMed 42572961 · DOI

Design
Systematic review and meta-analysis of 16 studies: 7 observational studies and 9 interventional studies.
Population
Adults with chronic kidney disease (CKD); 1,487 participants in observational studies, 581 participants in interventional studies.
Intervention
Vitamin D supplementation (interventional studies) and vitamin D status (observational studies), assessed for left ventricular remodeling.
Dose as studied
Not stated in the abstract.
Comparator
Not stated in the abstract.
Duration
Not stated in the abstract.

Outcomes, as reported

  • Left ventricular mass index (LVMI), observational studies Higher vitamin D levels associated with lower LVMI (r = -0.41, 95% CI: -0.64 to -0.11); heterogeneity substantial, certainty of evidence very low.
  • LVMI, interventional studies (supplementation) No significant improvement (SMD = -0.20, 95% CI: -0.62 to 0.22).
  • Left ventricular ejection fraction (LVEF), interventional studies No significant improvement (SMD = 0.57, 95% CI: -0.32 to 1.46).
  • Interventricular septal thickness (IVST), interventional studies Possible reduction (SMD = -0.68, 95% CI: -1.32 to -0.05), based on limited and inconsistent evidence.

Limitations stated by the authors · Substantial heterogeneity; very low certainty of evidence for the LVMI association; IVST finding based on limited, inconsistent evidence. Authors state larger, adequately powered, long-term randomized trials are needed.

Funding · Not stated in the abstract.