PubMed 42480243

Vegan multinutrient supplementation significantly increases Omega-3 index and 25-OH-vitamin D status: a randomized, double-blind, placebo-controlled trial in healthy young vegans

Zerback T et al. · Prostaglandins, leukotrienes, and essential fatty acids · 2026 · PubMed · DOI 10.1016/j.plefa.2026.102759

Summary

Drafted from the abstract by an automated step and checked field by field against that same abstract by another automated pass, not by a person. It reports what the authors reported, in their terms. It is not medical advice and it is not about any product on this site.

Vegan multinutrient supplement (26 µg vitamin D) plus omega-3 capsules with 36 or 72 µg vitamin D vs placebo in healthy vegan adults, 4 months

Randomized controlled trialMachine-checked Sep 21, 2026AI-assisted draft

Zerback T et al. Vegan multinutrient supplementation significantly increases Omega-3 index and 25-OH-vitamin D status: a randomized, double-blind, placebo-controlled trial in healthy young vegans. Prostaglandins, leukotrienes, and essential fatty acids, 2026. PubMed 42480243 · DOI

Design
Randomized, double-blind, placebo-controlled trial, 3 arms (single dose, double dose, placebo)
Population
72 healthy vegan adults aged 19 to 57 years. Setting not stated in the abstract; the trial is registered in the German Clinical Trials Register (DRKS00028151).
Intervention
A vitamin and mineral supplement providing 26 µg vitamin D, plus an omega-3 supplement in a single dose (EPA 98.7 mg, DHA 171.0 mg, additional vitamin D 36 µg, vitamin E 3.7 mg) or a double dose (EPA 197.4 mg, DHA 342.0 mg, additional vitamin D 72 µg, vitamin E 7.4 mg).
Dose as studied
Vitamin D 26 µg from the multinutrient plus 36 µg (single dose) or 72 µg (double dose) with the omega-3 supplement; dosing frequency not stated in the abstract.
Comparator
Placebo capsules
Duration
4 months

Outcomes, as reported

  • 25-hydroxyvitamin D Declined on average in the placebo group. Increased significantly in both supplement groups compared with placebo (p < 0.001). The double dose gave numerically larger increases than the single dose, but the difference between doses was not statistically significant.
  • Omega-3 index Declined on average in the placebo group. Increased significantly in both supplement groups (p < 0.001). The difference between the two doses was not statistically significant.
  • Vitamin E Unchanged, as expected; the authors state it was included only as an antioxidant in the omega-3 supplement.

Limitations stated by the authors · Clinical endpoints were not evaluated. The authors note that improved nutrient status may have implications for health but did not measure them.

Funding · Not stated in the abstract.